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CTAD 2022 Preview: Lecanemab Is Headliner After Gantenerumab’s Failure

Anti-Amyloid Debate Continues With Mixed Readouts

 
• By Mandy Jackson

Phase III results for Eisai/Biogen’s lecanemab are the main event at the Clinical Trials on Alzheimer’s Disease meeting, but other data – even Roche’s failed Phase III gantenerumab studies – also may have implications for the amyloid-clearing antibody. 

Brain image on blue background
Lecanemab's efficacy may hinge on the type of amyloid it clears from the brain • Source: Shutterstock

All eyes will be on the first presentation of detailed results for Eisai Co., Ltd./Biogen, Inc.’s amyloid-clearing antibody lecanemab from the Phase III Clarity AD trial at the Clinical Trials on Alzheimer’s Disease (CTAD) meeting from 29 November to 2 December in San Francisco. But data for other anti-amyloid therapies also may shed some light on what could make lecanemab stand out as it nears approval and launch.

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