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Arvinas And Pfizer’s Protein Degrader Shows Mixed Results In Breast Cancer

Data Accidentally Released Ahead Of Congress

 
• By Andrew McConaghie

The frontrunner in the new protein degrader class has shown lackluster Phase II results in breast cancer, but Arvinas hopes for success in less heavily pre-treated patients in Phase III.

Protein degradation
Arvinas is a leader in the field of protein degradation. • Source: Shutterstock

Arvinas and Pfizer’s ARV-471 is seen as the leading molecule in a new class of protein degrader drugs, and as such, its results in a Phase I/II study in metastatic breast cancer have been keenly awaited.

However, new data released from the Phase II single-arm VERITAC expansion cohort study in heavily pre-treated patients with locally advanced or metastatic ER positive/HER2

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