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Alzheimer’s Experts: Lecanemab Is A Win, But Also Just The Beginning

CTAD Panelists Cheer Eisai/Biogen Data, Note Challenges Ahead

 
• By Mandy Jackson

While Phase III results for Eisai and Biogen’s lecanemab show amyloid clearance provides benefit and Roche’s Phase III gantenerumab data are supportive, more data and certainty of access to treatment are needed.

Alzheimer's patient and caretaker
• Source: Shutterstock

The path to a disease-modifying treatment for Alzheimer’s disease is paved with failure after disappointing failure, so when the Phase III Clarity AD clinical trial of Eisai Co., Ltd./Biogen, Inc.’s lecanemab was presented on day one of the Clinical Trials on Alzheimer’s Disease (CTAD) meeting in San Francisco the data set a positive tone for the rest of the conference. Nevertheless, as AD experts noted during a panel on 1 December, the final day of CTAD, many challenges remain.

Eisai presented detailed results from Clarity AD on 29 November that showed lecanemab, an amyloid protofibril-targeting antibody, provided a 27% slowing of disease progression on the primary endpoint of Clinical...

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