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Argenx’s I.V. Vyvgart May See Continued Role In ITP, Despite SubQ Version Coming

 
• By Alaric DeArment

The company presented Phase III data for the I.V. formulation at ASH showing a high response rate in pretreated patients, a difficult-to-treat population. It also has a subcutaneous version in Phase III.

Array of blood samples for microscopy and biopsy tissue on blue gradient background

A subcutaneous formulation of argenx N.V.’s Vyvgart (efgartigimod alfa-fcab) – currently available as an intravenous drug – would no doubt benefit patients from a convenience standpoint. However, the intravenous formulation may continue to have significant utility as the company works to expand its labeling into primary immune thrombocytopenia (ITP), a type of rare platelet disorder.

The company presented updated data from its pivotal Phase III ADVANCE study of Vyvgart in ITP during an 11 December...

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