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Moderna Chalks Up Industry Milestone With mRNA Cancer Vaccine Efficacy Success

 
• By Joseph Haas

Phase IIb KEYNOTE-942 study shows mRNA-4157/V940 paired with Keytruda reduces risk of recurrence and death in post-surgical melanoma patients compared with Keytruda alone.

Moderna
Moderna gets key data for its personalized cancer vaccine • Source: Shutterstock

Moderna, Inc. and Merck & Co., Inc.'s success with an mRNA-based cancer vaccine in a Phase IIb trial could form the starting point for a broad new cancer franchise. The companies reported that a Phase IIb study in post-surgical stage III/IV melanoma patients yielded a 44% lower risk of recurrence or death for a combination of Moderna’s experimental mRNA personalized cancer vaccine and Keytruda versus Keytruda monotherapy.

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