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AbbVie’s Blockbuster Vraylar Adds Significant Indication, Adjunctive MDD

 
• By Joseph Haas

Already selling at a run rate above $2bn annually, AbbVie predicts the atypical antipsychotic could reach the $4bn mark with a new US indication for adjunctive treatment of major depressive disorder.

FDA approved
Adjunctive MDD is Vraylar's fourth US label indication • Source: Shutterstock

AbbVie Inc. has obtained a supplemental US approval for atypical antipsychotic Vraylar (cariprazine) that the company and at least one analyst believe could add a billion-dollar opportunity to the drug’s existing label. The Chicago pharma revealed late on 16 December that the US Food and Drug Administration approved Vraylar as an adjunctive treatment for major depressive disorder in adults.

A D3-preferring dopamine D3/D2 receptor partial agonist, Vraylar is approved in the US for bipolar disorder and schizophrenia. The bipolar...

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