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Vera’s Atacicept Passes Phase II IgAN Trial But Data Pale Beside Chinook’s Pipeline Rival

Pivotal Trial Plans Underway

 
• By Ayisha Sharma

The US biotech’s dual cytokine inhibitor has hit significance in a mid-stage trial with plans underway for a Phase III study, but concerns about its lacklustre efficacy when compared with a rival candidate from Chinook have taken the wind out of its sails.  

Red hot air balloons in a line against the sky, one red hot air balloon higher than the rest
Some Analysts Believe Chinook Could Have The Edge On Vera • Source: Shutterstock

Vera Therapeutics, Inc.’ immunoglobulin A nephropathy (IgAN) asset, atacicept, has succeeded in a Phase IIb trial, sparking plans for pivotal development in the first half of the year even as some experts maintain a rival candidate from Chinook Therapeutics, Inc. could prove superior.

Atacicept is recombinant fusion protein that binds to and inhibits B lymphocyte stimulator cytokines and proliferation-inducing ligand (APRIL) cytokines, both of which play a key role in promoting the B-cell survival

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