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Vera Pins Hopes On Per-Protocol Analysis To Revive Phase II IgAN Asset

As Firm Reprioritizes Resources

 
• By Ayisha Sharma

The US firm is shifting its focus to IgAN after a promising new prespecified analysis of its Phase II trial of atacicept lifted hopes for the product’s prospects as compared with a key rival candidate.  

Yellow line going down and then up, led by finger
Vera Is Determined To Advance Atacicept Into The Pivotal Stage • Source: Shutterstock

Vera Therapeutics, Inc.’s immunoglobulin A nephropathy (IgAN) asset, atacicept, has shown enhanced potential in a new prespecified per-protocol (PP) analysis from its Phase II ORIGIN trial, prompting the firm to pause other programs and redouble efforts in the renal disease.

Earlier this month, topline data were released from the ORIGIN intent-to-treat (ITT) population of 116 patients in which a pooled...

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