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Gilead’s Trodelvy Strategy Helped By Phase II Bladder Cancer Data

 
• By Joseph Haas

Two weeks after obtaining its third cancer indication and the same day Kite CEO Christi Shaw’s departure was announced, Gilead’s antibody-drug conjugate yielded Phase II data it says will help toward full approval in urothelial cancer.

Antibody-drug conjugate
Gilead continues working toward adding to ADC Trodelvy's label • Source: Shutterstock

Gilead Sciences, Inc. unveiled new and updated positive data from a Phase II trial of Trodelvy (sacituzumab govitecan-hziy) in metastatic urothelial cancer (mUC) on 17 February, part of a dataset the company hopes will expand the antibody-drug conjugate into second-line treatment of bladder cancer.

The updated readout from Phase II TROPHY-U-01 arrived just two weeks after the Foster City, CA-headquartered company announced on 3 February that Trodelvy obtained US Food and Drug Administration approval to treat HR+/HER2 metastatic breast cancer in patients who have received endocrine-based therapy and at least two additional systemic therapies in the metastatic setting – the second breast cancer indication for Trodelvy and its third indication overall

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