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Nektar Meets Failure Again, This Time In Phase II Lupus Study

 
• By Alaric DeArment

Nektar, which had multiple trial failures for cancer drug bempegaldesleukin last year, and Lilly will now focus on rezpegaldesleukin in atopic dermatitis. Nektar is planning significant cost reductions.

Nektar said the Phase II study of rezpeg in SLE failed • Source: Shutterstock

Nektar Therapeutics has encountered another failure of a drug in its pipeline, this time rezpegaldesleukin moderately to severely active systemic lupus erythematosus (SLE). The trial failure means neither it nor partner Eli Lilly and Company will move forward in that indication, though the companies are discussing next steps for a Phase IIb study of it in atopic dermatitis, and Nektar executives suggested that a future path forward in lupus may still exist as well.

Nektar announced topline data on 23 February from its Phase II randomized, placebo-controlled trial of rezpegaldesleukin in adults with SLE...

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