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Theravance Dumps JAK Inhibitor Program, Focuses On Neurogenic Orthostatic Hypotension

 
• By Alaric DeArment

Ampreloxetine failed in a Phase III trial in 2021, but the company will start a registrational trial by the end of Q1 for the drug in the multiple system atrophy population, where it has shown efficacy.

Theravance announced its fourth quarter and full year 2022 earnings • Source: Shutterstock

Theravance Biopharma Inc. is jettisoning its JAK inhibitor program and laying off nearly a fifth of its staff. Its second restructuring in two years, it will now concentrate on its marketed in-house product, the chronic obstructive pulmonary disease (COPD) drug Yupelri (revefenacin), as well as ampreloxetine, in Phase III for neurogenic orthostatic hypotension (nOH).

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