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Incyte’s Jakafi Flunks In Phase III Myelofibrosis Study As Loss Of Exclusivity Nears

 
• By Alaric DeArment

The company said it would discontinue the Phase III LIMBER-304 trial in patients who had inadequate response to Jakafi when an analysis indicated the study would not reach its primary endpoint.

Incyte said 6 March that it would discontinue the Phase III LIMBER-304 study • Source: Shutterstock

Incyte Corporation’s efforts to maintain Jakafi’s (ruxolitinib) place in the market before its exclusivity runs out hit a snag with the announcement that it stopped a combination trial of the drug in myelofibrosis because the study would not likely hit its primary endpoint.

Incyte said 3 March that it would discontinue the Phase III LIMBER-304 trial of Jakafi, a JAK inhibitor, with the PI3K-delta inhibitor parsaclisib in adult myelofibrosis patients who have inadequate response to Jakafi monotherapy

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