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Unity’s UBX1325 Faces Uncertain Path Forward In AMD, But DME Still Looks Promising

 
• By Alaric DeArment

The company said the Phase II ENVISION study of the drug in wet age-related macular degeneration did not show non-inferiority to Eylea, leaving it with an uncertain path forward in that indication.

Unity announced results from its Phase II study in wet AMD • Source: Shutterstock

The path ahead for UNITY Biotechnology, Inc.’s UBX1325 in patients with wet age-related macular degeneration (AMD) has become less straightforward as the company announced that its Phase II study did not show non-inferiority to Regeneron Pharmaceuticals, Inc.’s Eylea (aflibercept). Consequently, there is greater hope among analysts for Unity’s diabetic macular edema (DME) program, particularly the Phase II BEHOLD clinical trial of UBX1325, a program that has shown stronger data to date.

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