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Jemperli Results In Endometrial Cancer Help GSK Build ‘Backbone’ In Immunotherapy

Strong Results But Merck & Co’s Keytruda Also Competing

 
• By Andrew McConaghie

Latecomer PD-1/L1 drug Jemperli has achieved impressive Phase III results in first line endometrial cancer, and GSK hopes it can “redefine” care, especially in dMMR patients. Rival Merck, however, has other ideas.

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GSK needs its own PD1/L1 therapy 'backbone' on which to build future cancer therapy combinations. • Source: GSK

GSK has scored a hit with early results from a pivotal study of its PD-L1 inhibitor cancer therapy Jemperli, showing the drug significantly extended progression-free survival, the primary endpoint, when added to standard-of-care chemotherapy in patients with with primary advanced or recurrent endometrial cancer.

The company believes the interim results from the Phase III RUBY study show that Jemperli (dostarlimab) can “redefine” treatment of the condition, which, once approved in this indication, could give

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