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GSKs Gepotidacin Could Become First Novel Antibiotic For uUTIs In 20 Years

Following Pivotal Success

 
• By Ayisha Sharma

The UK major’s first-in-class asset has matched standard-of-care in two Phase III urinary tract infection trials, setting it up to become the first novel antibiotic for the condition in 20 years with a clear niche in the second-line setting.    

X-ray image of bladder, Showing cystitis or lower urinary tract infection
Around A Quarter Of Women Have Recurrent Urinary Tract Infections • Source: Shutterstock

GSK plc’s gepotidacin could bring a much-needed breakthrough to the neglected uncomplicated urinary tract infection (uUTI) space after two Phase III EAGLE studies in the condition showed the asset could at least match the efficacy of first-line gold standard treatment.

Gepotidacin is a first-in-class oral triazaacenaphthylene antibiotic that prevents bacterial DNA replication by inhibiting two different Type II topoisomerase enzymes

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