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AstraZeneca/Ionis’s Eplontersen Shows Competitive Efficacy In ATTR Polyneuropathy At 66 Weeks

US FDA Approval Pending With Decision Due In December

 
• By Mandy Jackson

Patients continued to improve across all three Phase III NEURO-TTRansform co-primary endpoints with 29 more weeks of treatment, setting up eplontersen to challenge Alnylam’s Amvuttra. 

many blue targets and three arrows hitting the center of the first one
Eplontersen met all three co-primary endpoints at 66 weeks • Source: Shutterstock

AstraZeneca PLC and Ionis Pharmaceuticals, Inc. hope to bring a best-in-class treatment for hereditary transthyretin-mediated amyloidosis (ATTR) to market, starting with ATTR polyneuropathy (ATTRv-PN), and have delivered longer-term results for eplontersen that could make their drug a strong competitor to Alnylam Pharmaceuticals Inc.’s Amvuttra (vutrisiran).

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Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.