Two months after Travere Therapeutics, Inc.’s Filspari (sparsentan) cleared the US Food and Drug Administration for treatment of immunoglobulin A nephropathy (IgAN), the company stumbled on its way to a second indication for the dual endothelin receptor antagonist. But even though the Phase III DUPLEX clinical trial of sparsentan in focal segmental glomerulosclerosis (FSGS) failed, Travere and its partner CSL Vifor plan to speak with US and EU regulators about potential paths to approval in FSGS.
Sparsentan Fails In Phase III FSGS Study, But Travere Assessing Path To Approval
No Readthrough Likely In Confirmatory IgAN Trial
Travere’s drug, approved as Filspari for immunoglobulin A nephropathy, missed its eGFR primary endpoints in focal segmental glomerulosclerosis but showed meaningful improvement in proteinuria.
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