Blueprint Sees Blockbuster Potential For Ayvakit In Systemic Mastocytosis With ISM Nod

The US FDA gave the drug a broad label in adults with indolent SM, without restrictions for disease severity or prior treatment, and Blueprint sees a potential $1.5bn market opportunity.

Blueprint Medicines announced the approval of Ayvakit in indolent systemic mastocytosis • Source: Shutterstock

Blueprint Medicines Corporation is anticipating a gradual ramp in sales for Ayvakit (avapritinib) in indolent systemic mastocytosis (ISM), starting with those who are already diagnosed, but it sees an opportunity to reach blockbuster sales if it can address even half of the overall ISM population.

On 22 May, the US Food and Drug Administration approved Ayvakit for ISM, making it the first and only drug...

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