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Arrowhead’s RNAi Gaining Momentum In Heart And Lung Targets

Shares Up By 25% On Pipeline Progress

 
• By Andrew McConaghie

Arrowhead has spent years in the shadows of rivals Alnylam and Ionis, but could make its mark with new ways to target cardiovascular and lung disease using RNA interference.

Arrowhead

Arrowhead has scored a Phase II success with its cholesterol-lowering candidate ARO-ANG3, adding to the momentum behind its RNA interference (RNAi) platform and pipeline.

The company has yet to bring its first drug to market, but partner Amgen now has its olpasiran (AMG 890), a novel lipoprotein(a) targeting RNAi candidate, in Phase III studies after promising mid-stage results

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