CDK4/6 inhibitors – Eli Lilly and Company’s Verzenio, Novartis AG’s Kisqali and Pfizer Inc.’s Ibrance – have proven efficacy in ER-positive/Her2-negative breast cancer, but a significant proportion of patients still relapse. CDK2 is receiving increasing attention as a possible answer to resistance to these drugs, and the American Society of Clinical Oncology (ASCO) annual meeting saw a couple of early data sets on some of the most advanced assets.
ASCO 2023 – Pfizer Pushes Forward In Drug-Resistant Breast Cancer
While Ibrance has been bested by class rivals Pfizer is working on projects that might overcome CDK4/6 inhibitor resistance, although it is not alone.
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