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Allogene May Have Cracked The Off-The-Shelf CAR-T Problem

42% Complete Response At Six Months Matches Auto-CAR-Ts

 
• By Andrew McConaghie

Allogeneic candidate’s durability is holding up thanks to a novel conditioning regimen, but Phase II data will be crucial test.

Allogene building

Allogene has taken a step closer to developing a viable off-the-shelf CAR-T therapy, becoming the first to match the durability of established autologous treatments after many years of setbacks and disappointments.

Its updated Phase I data presented at the American Society of Clinical Oncology congress show a complete response rate of 42% at six months post-treatment, based on five patients in...

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The Italian drugmaker gets rights to Phase III-ready asset radiprodil.

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