Lilly Wows ADA Crowd With Obesity Data Across Three-Drug Incretin Portfolio

Weight Loss Of Up To 24.2% With ‘Triple G’ Retatrutide

Lilly may gain its first US approval in obesity with Mounjaro before the end of 2023, but presented data at ADA for it and two other drugs – retatrutide and orforglipron – that also yielded significant weight loss.

Black and white scale on wood floor
Lilly presented data at ADA on three obesity drugs • Source: Shutterstock

Eli Lilly and Company is a few years behind Novo Nordisk A/S in bringing a GLP-1 agonist to market for obesity, but it presented data at the American Diabetes Association (ADA) annual meeting that could give the company a best-in-class portfolio of medicines, including its GLP-1/GIP/glucagon receptor (GGG) triagonist retatrutide, which generated weight loss of up to 24.2% in overweight and obese patients without diabetes at 48 weeks in a Phase II clinical trial presented on 26 June.

Novo Nordisk already markets the injectable GLP-1 agonist Wegovy (semaglutide) for obesity in the US and plans to submit its...

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required

More from Clinical Trials

Atai Gives Up On Recognify’s Schizophrenia Drug After Phase IIb Miss

Set to merge with Beckley Psytech, Atai will focus on psychedelic candidates for treatment-resistant depression while Recognify will analyze Phase IIb data for possible next steps.

Celcuity Preps For Potentially Huge Market After Phase III Gedatolisib Win

 

The biotech announced positive results in the PIK3CA wild-type population in second-line HR+/HER2- breast cancer for its PAM inhibitor.

Roche Unveils Alzheimer’s Phase III Plan And Preclinical Study

 

The trontinemab Phase III study is due to get underway this year, with Roche confident its brainshuttle technology will help it surpass approved rivals.

Bayer’s Elinzanetant Is Latest Drug Hit By FDA Review Delays

 
• By 

Comes Days After PDUFA Pushback For GSK's Blenrep.

More from R&D

Pipeline Watch: Twelve Approvals And Six Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.

Bristol Appoints AstraZeneca’s Massacesi As Next CMO

 

Chief Medical Officer Samit Hirawat will step down to pursue new career opportunities, the company said.

Boehringer Ingelheim Expects Two Key Approvals In Second Half Of 2025

 

The privately held German pharma firm is hoping to bring a new generation of pulmonary fibrosis and cancer drugs to market but their commercial success is not yet a certainty.