Eli Lilly and Company is a few years behind Novo Nordisk A/S in bringing a GLP-1 agonist to market for obesity, but it presented data at the American Diabetes Association (ADA) annual meeting that could give the company a best-in-class portfolio of medicines, including its GLP-1/GIP/glucagon receptor (GGG) triagonist retatrutide, which generated weight loss of up to 24.2% in overweight and obese patients without diabetes at 48 weeks in a Phase II clinical trial presented on 26 June.
Lilly Wows ADA Crowd With Obesity Data Across Three-Drug Incretin Portfolio
Weight Loss Of Up To 24.2% With ‘Triple G’ Retatrutide
Lilly may gain its first US approval in obesity with Mounjaro before the end of 2023, but presented data at ADA for it and two other drugs – retatrutide and orforglipron – that also yielded significant weight loss.

More from Clinical Trials
Aldeyra’s dry eye candidate reproxalap received a second FDA complete response letter, but the firm expressed confidence about refiling quickly based on two ongoing studies.
Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.
By allowing it to enter the brain more easily, trontinemab’s brain shuttle brings more patients to ‘amyloid zero’ levels faster, and with fewer brain swelling side effects.
Compass' bispecific antibody tovecimig hits primary efficacy endpoint in Phase II/III top-line data in advanced biliary tract cancer, and may have class side-effect advantages. But additional survival data may be needed to support US approval.
More from R&D
AstraZeneca remains committed to investing in R&D and alliances in China, where Susan Galbraith, the UK major’s head of oncology R&D, sees innovation eventually reaching parity with the US and Europe.
BeiGene’s Phase III ociperlimab joins the list of failed TIGIT inhibitors, as candidates from Roche, Merck & Co. and others have failed late-stage studies.
With new Phase II data, Edgewise asserted that EDG-7500, a sarcomere modulator, could offer better efficacy and safety than cardiac myosin inhibitors in hypertrophic cardiomyopathy.