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Path Forward For Viridian’s IGF-1R Antibody In Chronic TED Raises Questions

Pivotal Trial Amendment Controversial

 
• By Ayisha Sharma

The US firm’s potential rival to Horizon’s Tepezza, VRDN-001, showed positive signals in a small group of patients with chronic thyroid eye disease in a Phase I/II trial, but its decision to drop one planned dosing regimen from an upcoming pivotal trial has put off some analysts.  

bulging eye
TED Causes Double Vision, Pain And Proptosis (Bulging Eyes) • Source: Shutterstock
Key Takeaways:

  • VRDN-001 was associated with a mean 2.0mm reduction in proptosis as measured by MRI.

  • Viridian decided to omit a planned 8-dose regimen from its pivotal trial, set to start this year.

  • The firm is also set to initiate Phase I trials of a subcutaneous version of VRDN-001 this year.

Viridian Therapeutics, Inc

TED, also known as Graves’ disease, is a debilitating rare disorder characterized by inflammation within the orbit of the eye, leading to double vision, pain, proptosis (bulging eyes) and potential blindness

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