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Positive Early Signs For Acumen’s Bid To Go Beyond Leqembi In Alzheimer’s

Drugs Targets Most Toxic Amyloid Form

 
• By Andrew McConaghie

Phase I data shows the oligomer-targeting antibody was safe and effective, and Acumen will now move ahead to a potentially pivotal Phase II/III study in Alzheimer’s disease.

brain jigsaw 3

Now that Eisai and Biogen’s Leqembi (lecanemab) has gained full US approval and Lilly’s donanemab is not far behind, other companies are looking to develop safer and more effective rivals in the same amyloid-beta targeting class.

One of the most fancied pre-market companies is Acumen Pharmaceuticals, led by a group of ex-Lilly executives. Its antibody...

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BioNTech/BMS Bispecific Shows Early Promise In Small Cell Lung Cancer

 
• By Andrew McConaghie

An updated abstract from the World Conference on Lung Cancer has given analysts confidence in BioNTech’s VEGF-A/PD-L1 bispecific challenger

Discontinuations For Viking’s Oral Obesity Drug VK2735 Scare Investors

 
• By Joseph Haas

Analysts lauded the 13-week weight-reduction rates Viking’s oral dual GLP-1/GIP agonist showed in Phase II, but the firm’s stock tumbled 42% due to high discontinuation rates.

Interest In PTC’s Sephience Launch Overshadows FDA’s Vatiquinone Rejection

 
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PTC said it got a complete response letter for the Friedreich’s ataxia drug, with the agency asking for an additional clinical trial.

Boehringer Expands Eyecare Horizons With Palatin Collaboration

 
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The German company already had four eye disease candidates in Phase II development and sees promise in Palatin’s novel melanocortin receptor modulators.

More from R&D

Egetis Eyes Swift US Submission For Emcitate

 
• By Kevin Grogan

The Sweden-based firm is set for talks with the FDA on the regulatory path for its MCT8 deficiency candidate.

Third Sickle Cell Product From Pfizer’s Global Blood Buyout Hits Snag

 
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The drugmaker reported a negative Phase III study for inclacumab, after a partial clinical hold for osivelotor and pulling Oxbryta from the market.

Pipeline Watch: Seven Approvals And Five Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.