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ADC Therapeutics To Wind Up Zynlonta Study In Frail Patients After Deaths

Study To End Despite No Clear Link With Treatment

 
• By Andrew McConaghie

The company had hoped its antibody drug conjugate could help frail and elderly B-cell lymphoma patients ineligible for chemotherapy, but the trial will now close following patient deaths.

Frail Patient
The study aimed to help elderly patients who were frail and unfit for standard first line chemotherapy treatment.

ADC Therapeutics is to end a Phase II study of its antibody-drug conjugate Zynlonta in unfit or frail patients with previously untreated diffuse large B-cell lymphoma, after concluding the risks of the trial outweighed benefits.

That came after 12 patients out of 40 enrolled on the LOTIS-09 study died, including seven respiratory event-related deaths. The...

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