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Exelixis’s Cabometyx Two-For-Two In A Week As Neuroendocrine Tumor Study Hits Endpoint

 
• By Alaric DeArment

The announcement of the CABINET study’s success follows by days positive results for CONTACT-02 in prostate cancer, though NETs represent a smaller commercial opportunity.

Exelixis said the Phase III CABINET trial in neuroendocrine tumors met its primary endpoint • Source: Shutterstock

Exelixis, Inc. got its second bit of good news in the space of a week with positive results from a pivotal trial of Cabometyx (cabozantinib) in pancreatic and extra-pancreatic neuroendocrine tumors (NETs), following closely the announcement of success in a study of the same drug in prostate cancer. On the other hand, while the NETs indication is one of significant unmet need, it may be relatively small in terms of revenue potential.

The company announced 24 August that the data and safety monitoring board (DSMB) of the National Cancer Institute-sponsored and Alliance for Clinical Trials in Oncology-led Phase III CABINET trial unanimously...

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