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LIB Therapeutics Looks Competitive With Big Pharma in Hypercholesterolemia

 
• By Elizabeth Cairns

Phase III results with lerodalcibep are in the same ballpark as heavy-hitting established PCSK9 inhibiting drugs.

Cholesterol plaque in artery

The private US company LIB Therapeutics, LLC has sprung seemingly out of nowhere with impressive Phase III cholesterol-lowering data. Results of the LIBerate-HeFH trial in heterozygous familial hypercholesterolemia suggest that the group’s PCSK9 inhibitor, lerodalcibep, might be as effective as established drugs in this class, including Praluent and Repatha. 

The trial enrolled 478 patients with heterozygous familial hypercholesterolemia (HeFH), who were on stable, maximally tolerated statin therapy with or without additional oral lipid lowering therapy. Lerodalcibep, also called LIB003, was given subcutaneously at a dose of 300mg in a 1

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