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FibroGen Adrift After Yet Another Pamrevlumab Failure

 
• By Elizabeth Cairns

The asset appears to have a similar future in Duchenne muscular dystrophy as it has in idiopathic pulmonary fibrosis – to wit, none.  

Many arrows missed hitting target mark. Shot miss. Multiple failed inaccurate attempts to hit archery target. Business challenge failure metaphor. Flat cartoon isolated vector object illustration
• Source: Shutterstock

Expectations were not high for the latest trial of FibroGen, Inc.’s pamrevlumab in Duchenne muscular dystrophy (DMD); nevertheless, the connective tissue growth factor-targeted product has still contrived to disappoint. The failure was so emphatic it has cut the company’s value by a quarter, leaving the share price at just 96¢ on NASDAQ on 30 August. 

FibroGen began the Phase III LELANTOS-2 trial with the aim of showing that pamrevlumab could treat ambulatory patients – 73...

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