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Taking On Obesity The Hard Way

 
• By Elizabeth Cairns

Despite the astounding efficacy and commercial potential of incretins in obesity, many groups are trying different mechanistic approaches to the disease – if only to enable combinations.   

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The success of incretin mimetics – most notably Novo Nordisk Pharma AG’s Wegovy – in obesity is so extraordinary that large numbers of similarly acting agents are being pushed through clinical trials, their developers each hoping for a piece of the pie. What is perhaps less explicable is that other companies are pinning their hopes on obesity candidates with entirely different mechanisms.

Key Takeaways:
  • A wide range of non-incretin strategies are being trialed in obesity

Incretins are peptide hormones that are secreted in the gut in response to a meal, stimulating pancreatic β-cells to secrete...

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