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Anthos Changing Course With Factor XIa Inhibitor, Targeting Atrial Fibrillation Patients First

 
• By Joseph Haas

With a Phase II study stopped for efficacy in bleeding reduction, Anthos hopes to bring abelacimab, a dual Factor XI/XIa inhibitor to market to prevent strokes in a-fib patients and to treat cancer patients with thrombosis.

Privately held Anthos Therapeutics Inc.’s ambition to take on major players in the anticoagulant space with a dual Factor XI/XIa inhibitor got a boost on 18 September with the announcement that the Phase II AZALEA-TIMI-71 trial in atrial fibrillation patients at risk for thrombosis was stopped early due to “an overwhelming reduction in bleeding” versus the established direct oral anticoagulant (DOAC) Xarelto (rivaroxaban).

In an interview, Anthos CEO John Glasspool said the Cambridge, MA-based firm is now thinking of seeking a commercial partner...

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