Boehringer Ingelheim GmbH and Zealand Pharma A/S have initiated the Phase III program for their dual agonist of the GLP-1 and glucagon receptors, survodutide, in the treatment of obesity, revealing details on 5 October for three clinical trials designed to demonstrate competitive efficacy and tolerability. After Phase II data showed impressive 18.7% weight loss at the highest dose tested, the Phase III program’s biggest challenge may be to overcome adverse events that led to 28.6% of participants discontinuing treatment.
Key Takeaways
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Boehringer Ingelheim and Zealand Pharma initiated their Phase III program for GLP-1/glucagon receptor agonist survodutide in obesity with two pivotal trials and a cardiovascular outcomes trial.
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BI and Zealand are developing survodutide (BI 456906) for obesity, but not for type 2 diabetes – unlike GLP-1 agonist class leaders semaglutide, which Novo Nordisk A/S markets as...
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