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ESMO 23: Non-Squamous NSCLC Population Props Up Dato-DXd In TROPION-Lung01

 
• By Alexandra Shimmings

Data from a histological subgroup have come to the rescue for AstraZeneca and Daiichi Sankyo’s investigational antibody-drug conjugate Dato-DXd along with reassurance over its safety profile in advanced NSCLC, while overall survival data are still awaited.    

Lung Cancer

The European Society for Medical Oncology (ESMO) abstract release shows that AstraZeneca PLC and Daiichi Sankyo Co., Ltd. were right to temper expectations for the TROPION-Lung01 study of Dato-DXd (datopotamab deruxtecan) in non-small cell lung cancer, but the companies can take comfort in subgroup data that suggest its use case could be more convincing in the non-squamous population.

The TROP2-targeted antibody-drug conjugate is a key pipeline prospect for the firms to drive growth beyond 2025 and the less-than-effusive...

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Biogen Lays Out Cadence For Felzartamab Data In Kidney Diseases

 
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Pharma’s Space Trails Entering Transformative Era - Keytruda’s Been There

 
• By Anju Ghangurde

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In Brief: PolyPid’s D-PLEX100 Aces Phase III Trial, US Partner, Submission Eyed

 
• By Sushmita Panda

PolyPid's D-PLEX100 meets Phase III endpoints this time around, significantly reducing surgical point infections in abdominal colorectal surgery, and is set for a US approval submission early next year.