DURECT Corporation got disappointing Phase IIb data for its epigenetic modulator larsucosterol in alcohol-associated hepatitis (AH) on 7 November, but is hoping to convince both the US Food and Drug Administration and shareholders that there are still good reasons to take drug into Phase III based on secondary endpoint data showing a reduction in 90-day mortality rate compared with the standard of care.
Durect Eyes Phase III In Alcoholic Hepatitis Despite Phase IIb Miss
Durect thinks its epigenetic modulator shows promise with data showing reduction in 90-day mortality despite missing the primary endpoint of mortality and liver transplant rate.
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