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Lilly’s Zepbound: The Biggest-Selling Drug In The World, Ever?

 
• By Elizabeth Cairns and Edwin Elmhirst

Humira currently holds the record as the bestselling drug ever. But Keytruda is coming for its crown – and beyond that, Zepbound.  

Pills and dollars

The biggest selling pharmaceutical product in the history of the world is Humira (adalimumab). AbbVie Inc.’s antirheumatic has racked up nearly $220bn in cumulative revenues since its market debut in 2003, and despite generic competition is forecast to sell another $46bn out to 2028, according to sellside consensus compiled by Evaluate Pharma.

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