Gene editing, with which Vertex Pharmaceuticals Incorporated has seen success, is one thing; base editing may be another. Shares in Verve Therapeutics, Inc. cratered on the NASDAQ after data presented at the American Heart Association on 12 November revealed that two patients treated with Verve’s base-editing anti-cholesterol therapy VERVE-101 suffered severe cardiovascular events.
Audience Unimpressed By Verve’s Base Playing
Verve’s shares dropped hard on its recent Phase I data, and it might be up to Lilly to retore investor confidence.

More from Clinical Trials
Compass' bispecific antibody tovecimig hits primary efficacy endpoint in Phase II/III top-line data in advanced biliary tract cancer, and may have class side-effect advantages. But additional survival data may be needed to support US approval.
BeiGene’s Phase III ociperlimab joins the list of failed TIGIT inhibitors, as candidates from Roche, Merck & Co. and others have failed late-stage studies.
With new Phase II data, Edgewise asserted that EDG-7500, a sarcomere modulator, could offer better efficacy and safety than cardiac myosin inhibitors in hypertrophic cardiomyopathy.
Investing heavily in antibody-drug conjugates, AbbVie is pioneering a dual STEAP1xPSMA-targeting approach in prostate cancer, as other candidates advance.
More from R&D
Investing heavily in antibody-drug conjugates, AbbVie is pioneering a dual STEAP1xPSMA-targeting approach in prostate cancer, as other candidates advance.
Strong sales growth for the German group’s SGLT2 inhibitor in 2024
After a more than three-year hiatus, China's Hengrui has signalled its return to multiregional Phase III trials as it looks to globalize its innovative pipeline. Meanwhile, a number of other Chinese players have announced plans to kick off Phase III trials this year and beyond.