Dupixent Heralds The Age Of Biologics In COPD

A second pivotal hit positions Sanofi and Regeneron’s antibody for approval in COPD – but other biologics are coming fast.

Molecular model of an antibody
• Source: Shutterstock/Kateryna Kon

The results of Dupixent’s first pivotal chronic obstructive pulmonary disease (COPD) trial were good; the results of the second look even better. Top-line data from the Phase III NOTUS trial showed a significant 34% reduction in exacerbations over placebo at one year, beating the 30% seen in the identical BOREAS trial back in March (Also see "Dupixent Succeeds Where Other Biologic Drugs Failed – In COPD" - Scrip, 23 March, 2023.).

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