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Anavex Finds EXCELLENCE Trial To Be Ironically Named

 
• By Elizabeth Cairns

A failure in children with Rett syndrome sees the company’s market value cut by more than a third.  

Nearly two years ago, Anavex Life Sciences Corp. posted iffy results with blarcamesine in a Phase III trial in adult Rett syndrome patients, prompting a share price fall. Now history has repeated, after a fashion, with data from a late-stage trial of the same drug in pediatric Rett patients sending the stock down 35%.

Key Takeaways
  • Anavex’s blarcamesine has failed in a Phase II/III trial in pediatric Rett syndrome patients
  • The disappointment has echoes of a questionable Phase III readout in adults with the same disease two years ago
  • The path forward

The company appeared to claim a hit on one of the EXCELLENCE trial’s two primary endpoints, saying the product “showed improvement,” but a close reading of the

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