Sage Ready To Turn Over Cards On Bets Outside Of Depression

Five Clinical Trial Readouts Expected In 2024

 
• By Mandy Jackson

Sage has two postpartum depression drugs on the market, but will read out mid-stage trials this year for two candidates in Huntington’s, Parkinson’s and Alzheimer’s diseases and essential tremor.

Set of abstract dots and lines brain logotypes concept
Sage has multiple brain health program readouts in 2024 • Source: Shutterstock

The US Food and Drug Administration review last year regarding Sage Therapeutics, Inc./Biogen, Inc.’s Zurzuvae (zuranolone) was not a sure bet and resulted in a split decision – approval for postpartum depression (PPD), but not for major depressive disorder (MDD). This year, Sage is focused on Zurzuvae’s PPD launch, while also preparing to turn over the cards on two new bets, both outside of the depression market.

Key Takeaways

  • 2024 is a big one for Sage as it is the first full launch year for Zurzuvae (zuranolone) in postpartum depression, but the company is also expecting several data readouts from its R&D pipeline.

Zurzuvae, an oral positive allosteric modulator (PAM) of the GABA-A receptor, is Sage’s second drug for PPD after the approval...

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