Kyverna Therapeutics Inc. took advantage of the growing excitement for chimeric antigen receptor T-cell (CAR-T) therapies in the treatment of autoimmune diseases by raising $319m in an initial public offering – the second-largest of the seven biopharmaceutical IPOs so far in the US this year. The proceeds will fund ongoing and planned clinical trials for its lead CAR-T candidate, CD19-targeting KYV-101, in the treatment of lupus nephritis, systemic sclerosis, multiple sclerosis and myasthenia gravis.
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