Sylentis Piles On Another Failure In Dry Eye

The PharmaMar subsidiary is the latest group to crash in a notoriously hard-to-treat disease, leaving Bausch + Lomb more firmly in command of the field.      

Eye drops

At first glance, the curious thing about the failure of Sylentis S.A.U.’s tivanisiran in a Phase III trial in dry-eye disease associated with Sjögren’s syndrome is that it follows a late-stage hit in standard dry eye disease. Look closer, however, and there is little evidence of the drug’s efficacy to be gleaned from either trial.

Key Takeaways
  • Sylentis’s RNAi drug tivanisiran has failed in Phase III in dry-eye disease associated with Sjögren’s syndrome

The FYDES trial, tivanisiran’s success in which was disclosed in December, was simply a safety study: no efficacy endpoints were...

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