At first glance, the curious thing about the failure of Sylentis S.A.U.’s tivanisiran in a Phase III trial in dry-eye disease associated with Sjögren’s syndrome is that it follows a late-stage hit in standard dry eye disease. Look closer, however, and there is little evidence of the drug’s efficacy to be gleaned from either trial.
Key Takeaways
- Sylentis’s RNAi drug tivanisiran has failed in Phase III in dry-eye disease associated with Sjögren’s syndrome
The FYDES trial, tivanisiran’s success in which was disclosed in December, was simply a safety study: no efficacy endpoints were...
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