Alnylam/Roche Score Another Phase II Win With Zilebesiran

Positive topline results from the KARDIA-2 study in hypertension mean there are now two Phase II trials down with one more to go before a planned pivotal cardiovascular outcomes trial.

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Alnylam Pharmaceuticals Inc. has added to the growing pile of data supporting its Roche Holding AG-partnered RNA-interference drug zilebesiran for high blood pressure with positive results from another Phase II study, which have prompted the company to launch another Phase II trial in patients with more severe disease, with an eye toward a future Phase III pivotal trial.

The drug maker released topline results from the KARDIA-2 study 5 March, with additional results to come at the American College of Cardiology annual meeting in April

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