Following on Bristol Myers Squibb Company’s US Food and Drug Administration approval of the first-in-class TYK2 inhibitor Sotyktu (deucravacitinib) for moderate-to-severe plaque psoriasis in late 2022, numerous other firms are lining up to develop the next TYK2-targeting agent for autoimmune diseases. Alumis, Inc., with positive Phase II data, thinks it might have a best-in-class molecule in ESK-001.
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