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Acelyrin PsA Data Are Positive, But Is Its IL-17 Blocker Competitive?

 
• By Joseph Haas

Troubled since a miss in hidradenitis suppurativa last fall, Acelyrin’s izokibep succeeded in a psoriatic arthritis trial, but will the drug compete well against other IL-17 inhibitors?

Psoriatic arthritis
Acelryin hopes izokibep will be competitive in the PsA space • Source: Shutterstock

After disappointing its shareholders with Phase IIb/III data for IL-17a inhibitor izokibep in hidradenitis suppurativa (HS) last September, Acelyrin, Inc. reported Phase IIb/III data for the drug in psoriatic arthritis on 11 March that it claims will be competitive in that space, including a potential safety edge compared to a pair of investigational IL-17a/f inhibitors. Investors appeared to agree with the sentiment on 11 March, but at least one analyst said the PsA data do not look competitive.

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