Seelos Aims For Conservative Approach After ALS Drug Shows Efficacy Signal

CEO Raj Mehta told Scrip Seelos anticipates conducting a Phase III study of SLS-005 after the cohort in HEALEY ALS failed overall, but indicated some efficacy in patients not receiving Relyvrio.

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Shortly after a Phase III trial failed to confirm Amylyx Pharmaceuticals, Inc.’s Relyvrio benefit in amyotrophic lateral sclerosis (ALS), Seelos Therapeutics, Inc. has revealed that its investigational drug SLS-005 did not meet the primary endpoint in a mid- and late-stage basket study, but showed an efficacy signal in patients who had not taken Relyvrio.

Seelos announced topline results from the Phase II/III HEALEY ALS Platform trial for SLS-005 (trehalose I.V.) 19 March, showing an...

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