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eFFECTOR's Tomiversib Flops In Lung Cancer, Hopes Rest On AML

 
• By Alaric DeArment

The company still sees a potential path forward for tomivosertib in acute myeloid leukemia, where its mechanistic rationale is distinct from the one in NSCLC.

• Source: Shutterstock

eFFECTOR Therapeutics, Inc. is placing its bets on a breast cancer drug candidate following the failure in a mid-stage trial of tomivosertib for non-small cell lung cancer (NSCLC), an indication where some had forecast blockbuster sales. However, the company is not yet giving up on tomivosertib, which is also in early-stage development for acute myeloid leukemia (AML).

The biotech company announced 4 April that the Phase II KICKSTART trial combining tomivosertib with Merck & Co., Inc

Key Takeaways

  • eFFECTOR Therapeutics said tomivosertib did not show sufficient efficacy in the Phase II KICKSTART trial combining it with Merck’s Keytruda in NSCLC.

  • The company still sees a potential path forward for the drug in AML, while another candidate, zotatifin, remains under development in breast cancer

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