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Can Organovo Leverage Its Solid Phase II Data In MASH?

 
• By Joseph Haas

Cash-limited Organovo has an FXR agonist showing competitive efficacy and tolerability in MASH, but may need a partner to move forward in that disease as it may be prioritizing its IBD program.

Young woman suffering from itching on her skin and scratching an itchy place. Allergic reaction to insect bites, dermatitis, food, drugs. Health care concept. Allergy rash - Image
Organovo's candidate shows better pruritus data than others in its class.

The idea of an FXR agonist being the solution for treating metabolic function-associated steatohepatitis (MASH) took a substantial hit when Intercept Pharmaceuticals, Inc. ended development of obeticholic acid (OCA) in the disease. However, Organovo Holdings, Inc. has now reported Phase II data for an FXR agonist that shows hepatic fat-reducing ability as well as a cleaner safety and tolerability profile than typically seen with the drug class.

Key Takeaways

  • Organovo, which uses its bioprinting capabilities to produce 3D disease models, reported Phase II data in MASH that looks competitive compared to other FXR agonists.

Previously focused on bioprinting, research tools and tissue for direct therapy, Organovo in recent years has used its ability to...

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