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AstraZeneca And Daiichi Get Low

 
• By Elizabeth Cairns

A hit with Enhertu in an earlier setting in HER2-low breast cancer patients, and in ultralow expressers, heightens expectations.    

Meter with low reading
• Source: Shutterstock

The long-awaited topline success of Daiichi Sankyo Co., Ltd. and AstraZeneca PLC’s DESTINY-Breast06 trial of their antibody-drug conjugate Enhertu is significant twice over. Firstly it could allow the product to move ahead of chemotherapy in breast cancer patients with high or low expression of HER2, for whom it is already largely established as standard-of-care post-chemo.

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Pipeline Watch: Five Approvals And One Phase III Readout

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.

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• By Sushmita Panda

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• By Vibha Ravi

Funding cuts at the National Institutes of Health, big pharma’s US onshoring moves, GCC partnerships and talks with the Indian government to solve intellectual property challenges are discussed in an interview with Aragen’s CEO, who is also keenly watching the Trump administration’s moves on pharma tariffs

Merck Set To Add Perioperative Head-And-Neck Cancer To Keytruda Label

 
• By Joseph Haas

With positive data versus radiation therapy in KEYNOTE-689, Merck & Co. files for approval in perioperative head and neck cancer, adding to additional claim in that cancer type.