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Annovis Faces A Race Against Time

 
• By Elizabeth Cairns

Buntanetap has flopped in Alzheimer’s disease, making an upcoming Parkinson’s trial a must-win. But there are reasons to doubt the outcome of this study, and Annovis is running out of money.    

Sand running through the bulbs of an hourglass measuring the passing time in a countdown to a deadline, on a dark background with copy space.

The trouble with having two primary endpoints on a clinical trial is it gives the drug two chances to fail. Annovis Bio, Inc. learned this lesson the hard way yesterday, after it admitted – eventually – that its mid-stage trial of buntanetap in Alzheimer’s had hit just one of its two main outcome measures, and even then only in a subset of patients.

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